ABSTRACT
Glimepiride is an antidiabetic drug of sulfonylurea group and indicated for the treatment of type 2 diabetes mellitus. The present study was conducted to enhance the dissolution rate of glimepiride solid lipid nano particle dispersions using hot homogenization method and glimepiride solid dispersion by precipitation method. Solid lipid nanoparticles have been used as suitable carriers for delivery of drug with poor solubility. In this investigation glyceryl monostearate and stearic acid were used as solid lipid, Lutrol F-68 as surfactant, Tween 80 as stabilizer and the used polymer were urea crystal and β-cyclodextrin. Three formulations were prepared in different ratios for two methods and were designated as GMLN1 to GMLN3 in case of hot homogenization method and GMP1 to GMP3 for precipitation method. The evaluation of all the dispersions were done by in vitro dissolution studies using US Pharmacopeia type II apparatus (paddle method) in 900ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C for 45 minutes. In situ and externally sink method revealed the release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improved dissolution profile was observed in all the solid lipid nano particle dispersions as compared to pure drug as well as market preparation. Thus, glyceryl monostearate and β-cyclodextrin can be successfully used as carrier for improvement of dissolution and bioavailability of glimepiride.
ABSTRACT
Glimepiride is an antidiabetic drug of sulfonylurea group and indicated for the treatment of type 2 diabetes mellitus. The present study was conducted to enhance the dissolution rate of glimepiride solid lipid nano particle dispersions using hot homogenization method and glimepiride solid dispersion by precipitation method. Solid lipid nanoparticles have been used as suitable carriers for delivery of drug with poor solubility. In this investigation glyceryl monostearate and stearic acid were used as solid lipid, Lutrol F-68 as surfactant, Tween 80 as stabilizer and the used polymer were urea crystal and β-cyclodextrin. Three formulations were prepared in different ratios for two methods and were designated as GMLN1 to GMLN3 in case of hot homogenization method and GMP1 to GMP3 for precipitation method. The evaluation of all the dispersions were done by in vitro dissolution studies using US Pharmacopeia type II apparatus (paddle method) in 900ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C for 45 minutes. In situ and externally sink method revealed the release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improved dissolution profile was observed in all the solid lipid nano particle dispersions as compared to pure drug as well as market preparation. Thus, glyceryl monostearate and β-cyclodextrin can be successfully used as carrier for im-provement of dissolution and bioavailability of glimepiride.
ABSTRACT
Dexamethasone is a type of steroid medication having anti-inflammatory and immunosuppressant effects. One of the major problems with this drug is its low solubility in water which results into poor bioavailability after oral administration. So the objective of the present work is to improve the solubility and dissolution rate of dexamethasone using its solid lipid nano particles (SLNPs) with stearic acid as solid lipid, lutrol F-68 as surfactant and tween-80 as stabilizer. SLNPs are prepared by hot homogenization method at different ratio of drug, lipid, surfactant and stabilizer and designated as DNP1 to DNP6. In vitro dissolution study was performed using the USP type II apparatus (paddle method) at 50 rpm to a temperature of 37°±0.5°C in distilled water containing 0.75% w/v SLS (sodium lauryl sulfate). The absorbance of sample was measured spectrophotometrically at λmax 239nm on a UV-Visible spectrophotometer. Release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improvement of dissolution was observed in all the solid lipid nano particles as compared to pure drug. Pure drug showed only 27.25% release in 50 min whereas the dexamethasone SLNPs showed faster (66.19%) in vitro drug release. Hence, this finding indicates that dexamethasone SLNPs prepared by hot homogenization method can be used to enhance the dissolution rate and to show novel application to this drug delivery system.
ABSTRACT
Dexamethasone is a type of steroid medication having anti-inflammatory and immunosuppressant effects. One of the major problems with this drug is its low solubility in water which results into poor bioavailability after oral administration. So the objective of the present work is to improve the solubility and dissolution rate of dexamethasone using its solid lipid nano particles (SLNPs) with stearic acid as solid lipid, lutrol F-68 as surfactant and tween-80 as stabilizer. SLNPs are prepared by hot homogeniza-tion method at different ratio of drug, lipid, surfactant and stabilizer and designated as DNP1 to DNP6. In vitro dissolution study was performed using the USP type II apparatus (paddle method) at 50 rpm to a temperature of 37°±0.5°C in distilled water containing 0.75% w/v SLS (sodium lauryl sulfate). The absorbance of sample was measured spectrophotometrically at λmax 239nm on a UV-Visible spectrophotometer. Release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improvement of dissolution was observed in all the solid lipid nano particles as compared to pure drug. Pure drug showed only 27.25% release in 50 min whereas the dexamethasone SLNPs showed faster (66.19%) in vitro drug release. Hence, this finding indicates that dexamethasone SLNPs prepared by hot homogenization method can be used to enhance the dissolution rate and to show novel application to this drug delivery system.
ABSTRACT
Triterpenoids and phytosteroids from stem bark of Crataeva nurvala buch ham.